New Delhi Metallo 1: Have Carbapenems Met Their Doom?
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چکیده
منابع مشابه
New Delhi metallo 1: have carbapenems met their doom?
Lise E. Nigrovic, Richard Malley, Dewesh Agrawal, and Nathan Kuppermann, for the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics Divisions of Emergency Medicine and Infectious Diseases, Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts; Division of Emergency Medicine, Children’s National Medical Center and George Was...
متن کاملNew Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised.
BACKGROUND Carbapenems are among the few useful antibiotics against multidrug resistant gram negative bacteria particularly those with extended spectrum beta lactamase. However resistance to carbapenems occurs and is mediated by mechanisms like loss of outer membrane proteins and production of beta lactamase that is capable of hydrolyzing carbapenems. An alert issued in the UK in 2009 warned of...
متن کاملNew Delhi metallo-β-lactamase-1: detection and prevention.
1240 CMAJ, August 9, 2011, 183(11) © 2011 Canadian Medical Association or its licensors The advent of New Delhi metallo-β lactamase-1 (NDM-1) as a new mechanism of microbial resistance went mostly unmarked, despite it being plasmidmediated, highly transferable and able to confer resistance to most antibiotics (with the exceptions of colistin and tigecycline). However, after the Indian subcontin...
متن کاملNew Delhi Metallo-β-Lactamase, Ontario, Canada
To the Editor: The New Delhi metallo-β-lactamase (NDM-1) was fi rst characterized in 2009 from Kleb-siella pneumoniae and Escherichia coli isolated from a patient in Sweden who had received medical care in New Delhi, India (1). Further studies have shown broad dissemination of this β-lactamase gene (bla NDM-1) in India, Pakistan, Bangladesh, and the United Kingdom (2). Additional isolates have ...
متن کاملRapidly emerging novel metallo beta lactamase--New Delhi metallo beta lactamase-1 (NDM-1)--is it a misnomer.
Metallo β-lactamases is the name given to certain enzymes found in gram negative bacteria belonging to Enter-obacteriaceae which confers resistance to all β-lactam antibiotics including carbapenems except monobactams. They belong to Ambler molecular class B and Bush-Jacoby-Medeiros Group 3.1,2 Resistance to carbapenems due to production of metallo β-lactamases in Gram Negative organisms is an i...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2010
ISSN: 1058-4838,1537-6591
DOI: 10.1086/656921